The search for eternal youth is nothing new. But if the best serums for wrinkles are any clue, we’re getting closer and closer to finding some semblance of that—for skin, at least. While the popularity of these fine line-fighting face serums hasn’t changed, the people using them have. These days, consumers are becoming much more savvy about what’s inside their serums—and the formulas, as a result, are evolving accordingly. They’re moving beyond mere hydration or a single active ingredient. “Retinoids and antioxidants are still incredibly important, but now there is much more attention being paid to peptides, growth factors, and other technologies that target different aspects of skin aging,” says Dr. Melanie Palm, MD, a board-certified dermatologist in Solana Beach, CA.
Vogue’s Top Serums for Wrinkles
But in an age of injectables and lasers, where do these anti-aging serums fall in your skin care routine? Consider them complements rather than competitors. “I often tell patients that in-office treatments are only part of the equation,” says Dr. Palm. “What you’re putting on your skin every morning and every night matters because you’re doing it 365 days a year.”
While no serum is going to deliver the results of a facelift, that doesn’t mean it’s not doing anything. Topical face serums can indeed make a world of difference in fine lines, uneven skin texture, pigmentation, and dryness. In fact, if you’re investing in procedures like neuromodulator and filler injections or lasers, “it makes sense to support and protect the skin between those appointments,” Dr. Palm says.
In This Article
Not only have the best wrinkle serums evolved, but they’ve also multiplied—meaning there are more options than ever for keeping skin firm, supple, and radiant. With that in mind, scroll ahead to find those that dermatologists and editors alike count on.
Best Overall: SkinMedica TNS Advanced+ Serum
SkinMedica
TNS Advanced+ Serum
- Why we love it: Many dermatologists point to this fragrance-free serum as a gold standard for those with mature skin, as it uses “a unique growth-factor blend and mix of peptides that promote skin regeneration and collagen production,” says Dr. Tiffany Libby, MD, a board-certified dermatologist in Providence. (Growth factors are produced by stem cells; they help with healing and skin rejuvenation, effectively directing skin cells to act more youthfully.) That combination can address fine lines and sagging skin in particular, according to says Dr. Gloria Lin, MD, a board-certified dermatologist in New York. The sleek tube houses two separate chambers: One offers a blend of growth factors and peptides, while the other contains peptides alongside a blend of botanicals that help support key functions to repair and renew skin.
- Ingredients: Human fibroblast conditioned media, peptides, green microalgae
- Size: 1 fl. oz.
- Best for: All skin types, but especially those with sun damage and signs of aging
- Fragrance-Free: Yes
